Some inflammatory cytokines may contribute to the development and progression of heart failure by promoting myocardial hypertrophy, provoking contractile dysfunction, and inducing apoptosis. 一些炎症因子能通过促进心肌细胞肥厚、恶化心肌收缩功能以及诱导凋亡,在心衰的发展过程中具有重要作用。
Result: The scores of inflammatory cell infiltration and smooth muscle hypertrophy were significantly higher in the cases of small airway lesion than in the normal. 结果:小气道病变组炎性细胞浸润、平滑肌肥厚积分明显高于正常组;
CONCLUSION: Excessive expression of myocardial ICAM 1 and its mediated inflammatory cellular infiltration plays an important role in hypertensive left ventricular hypertrophy. 结论:心肌细胞间黏附分子1的过度表达及其介导的炎性细胞浸润在高血压左室肥厚的发病过程中具有重要作用。
Inflammatory cytokines promote the progression of cardiac remodeling in various ways, including cardiomyocytes hypertrophy, cell apoptosis and extracellular matrix synthesis and degradation. 大量研究表明,炎性细胞因子可通过诱导心肌细胞肥大、细胞凋亡、调节细胞外基质的合成和降解等多种途径参与心脏重构的形成。